Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:FunctioniTranscriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity."Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION. RegionsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsZinc fingeri25C2H2-type 1Zinc fingeri25C2H2-type 2Zinc fingeri23C2H2-type 3GO - Molecular functioniGO - Biological processiKeywords - Molecular functioniKeywords - Biological processi, , Keywords - Ligandi, , Names & TaxonomyiProtein namesiRecommended name:Krueppel-like factor 10Alternative name(s):Transforming growth factor-beta-inducible early growth response protein 1Short name: TGFB-inducible early growth response protein 1Short name: TIEG-1Zinc finger transcription factor homolog CPG20Gene namesiName:Klf10Synonyms:Cpg20, Tieg, Tieg1OrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Chromosome 7 Organism-specific databases
RGDi Klf10. Subcellular locationi "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION. GO - Cellular componentiKeywords - Cellular componentiPTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini480Krueppel-like factor 10PRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsModified residuei1PhosphoserinePost-translational modificationiU mediated by SIAH1 and leading to its subsequent proteasomal degradation.Keywords - PTMi, Proteomic databases
PRIDEi ExpressioniInductioniUp-regulated in response to glucose."Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION. Gene expression databases
Genevisiblei RN. InteractioniProtein-protein interaction databases
STRINGi Structurei3D structure databases
ProteinModelPortali
MobiDBiFamily & DomainsiSequence similaritiesiBelongs to the .Contains 3 s.Zinc fingerFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsZinc fingeri25C2H2-type 1Zinc fingeri25C2H2-type 2Zinc fingeri23C2H2-type 3Keywords - Domaini, Phylogenomic databases
InParanoidi
PhylomeDBi
TreeFami Family and domain databases
Gene3Di 3 hits.
InterProi Znf_C2H2.
Znf_C2H2-like.
Znf_C2H2/integrase_DNA-bd.
SMARTi ZnF_C2H2. 3 hits.
PROSITEi ZINC_FINGER_C2H2_1. 3 hits.
ZINC_FINGER_C2H2_2. 3 hits.
[]SequenceiSequence statusi: Complete.O08876-1 []
50MLNFGASLQQ ASEGKMELIS EKSKEGAHPW DKAEQSDFEA VEALMSMSCD
100WKSHFKKYLE NRPVTPVSDT SEEDSLLPGT PDLQTVPAFC LTPPYSPSDF
150EPSQGSNLTA PAPPTGHFRS LSDAAKPPSI APFKEEEKSP LAAPPLPKAQ
200ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHI NVEATRKNIP
250CAAVSPNRPK PEPSTAANGA EKAGTAPYDF AVPSSETVIC RSSQPAPTSP
300VQKSVLMSSP TVSTGGVPPL PVICQMVPLP ANNSLVTTVV PSSPPSQPPA
350VCSPVLFMGT QVPKGTVMFV VPQPVVQSPK PPVVSPNGTR LSPIAPAPGF
400SPSAARVTPQ IDSSRVRSHI CSHPGCGKTY FKSSHLKAHV RTHTGEKPFS
450CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
480HLSAKKLPNW QMEVSKLNDI ALPPATASAQ
48051,829July 1, 1997 - v1Checksum:iEE029BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: .
UniGeneiGenome annotation databases
Ensembli; ; .
UCSCi rat. Cross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: .
UniGenei3D structure databases
ProteinModelPortali
MobiDBiProtein-protein interaction databases
STRINGi Proteomic databases
PRIDEi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
Ensembli; ; .
UCSCi rat. Organism-specific databases
RGDi Klf10. Phylogenomic databases
InParanoidi
PhylomeDBi
TreeFami Miscellaneous databases
PROi Gene expression databases
Genevisiblei RN. Family and domain databases
Gene3Di 3 hits.
InterProi Znf_C2H2.
Znf_C2H2-like.
Znf_C2H2/integrase_DNA-bd.
SMARTi ZnF_C2H2. 3 hits.
PROSITEi ZINC_FINGER_C2H2_1. 3 hits.
ZINC_FINGER_C2H2_2. 3 hits.
ProtoNetiPublicationsi"Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms.", , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: . "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: . "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION. +MiscellaneousiKeywords - Technical termi, Documents
Index of protein domains and families
External DataSimilar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.免费用户下载点
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