Lack of tumour pigmentation in conjunctival melanoma is...
18.96Leiden University Medical Centre+ 141.62Leiden University Medical CentreShow more authorsAbstractAim
To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma.
Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses.
A light iris colour (blue, grey, green) was present in 261 (59%) patients and a dark colour (hazel, brown) in 183 (41%). A low tumour pigmentation was detected in 130 (40%) and a high pigmentation in 197 (60%) patients. Low tumour pigmentation was associated with light iris colour (p=0.021) but not related to skin colour (p=0.92). In univariate analysis, neither iris nor skin colour was related to clinical outcome, while a low tumour pigmentation was related to metastasis formation (HR 2.37, p=0.004) and death (HR 2.42, p=0.020). In multivariate analysis, low tumour pigmentation was related to the development of recurrences (HR 1.63, p=0.043), metastasis formation (HR 2.48, p=0.004) and death (HR 2.60, p=0.014).
Conclusion
Lightly pigmented tumours occurred especially in individuals with lightly coloured irises. While iris colour or skin colour was not significantly related to clinical outcome, a low tumour pigmentation was related to a worse outcome in patients with conjunctival melanoma. The amount and type of melanin in conjunctival melanocytes may be involved in the pathogenesis and behaviour of selected conjunctival melanoma.Do you want to read the rest of this article?Request full-text
This research doesn't cite any other publications.Project[...]My main research interest is in autoimmune aspects of retinal disorders, including autoimmune retinopathies, uveitis, optic neuritis, and autoimmune neuropathies. We study the role of autoantibodie…& [more]Project[...]Developing protontherapy treatment for uveal melanoma in HollandPTC (www.HollandPTC.nl).
Research into clinical results with both Protontherapy and ruthenium brachytherapy and QOL in uveal melanoma…& [more]Project[...]ArticleNovember 2016 · Purpose:
This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma.
Clinical and histopathological examination of the pigmented conjunctival lesions was performed.
A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following... [Show full abstract]ArticleNovember 2017 · Aims
To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management.
A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data... [Show full abstract]ArticleDecember 2017 · ArticleSeptember 2017Purpose: To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies.
Methods: Clinical and histopathological examination of the conjunctival lesion.
Results: A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5... [Show full abstract]ArticleSeptember 2011 · Purpose To evaluate the role of 3 Tesla MRI in the diagnosis, measurement and treatment planning of choroidal and iridociliary melanoma and comparison of results with Ultrasound and histology to measure the accuracy of MRI.Methods : Prospective analyses of consecutive 12 patients, four with iridociliary and eight having choroidal melanocytic tumors. All these patients had ultrasound (10MHz) or... [Show full abstract]Last Updated: 31 May 18Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis.
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2018 May 21. doi: 10.57.. [Epub ahead of print]Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis.1,2, 1, 3, 2,3.1ORIGEN - Center for Reproductive Medicine, Rio de Janeiro, Brazil.2Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.3ORIGEN - Center for Reproductive Medicine, Belo Horizonte, Brazil.AbstractOBJECTIVE: To evaluate if there are differences in the risks of obstetric outcomes in IVF/ICSI singleton pregnancies when compared fresh to frozen-thawed embryo transfers (FET).METHODS: This was a systematic review and meta-analysis evaluating the obstetric outcomes in singleton pregnancies after FET and fresh embryo transfer. The outcomes included in this study were pregnancy-induced hypertension (PIH), pre-eclampsia, placenta previa, and placenta accreta.RESULTS: The search yielded 654 papers, 6 of which met the inclusion criteria and reported on obstetric outcomes. When comparing pregnancies that arose from FET or fresh embryo transfer, there was an increase in the risk of obstetric complications in pregnancies resulting from FET when compared to those emerging from fresh embryo transfers in PIH (aOR 1.82; 95% CI 1.24-2.68), pre-eclampsia (aOR 1.32, 95% CI 1.07, 1.63), and placenta accreta (aOR 3.51, 95% CI 2.04-6.05). There were no significant differences in the risk between the FET and fresh embryo transfer groups when evaluating placenta previa (aOR 0.70; 95% CI 0.46-1.08).CONCLUSION: The obstetric outcomes observed in pregnancies arising from ART may differ among fresh and FET cycles. Thus, when evaluating to perform a fresh embryo transfer or a freeze-all cycle, these differences found in obstetric outcomes between fresh and FET should be taken into account. The adverse obstetric outcomes after FET found in this study emphasize that the freeze-all policy should not be offered to all the patients, but should be offered to those with a clear indication of the benefit of this strategy.KEYWORDS: O f frozen-th placentaPMID:
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External link. Please review our .大黄联合谷氨酰胺对急性肝衰竭模型大鼠肝功能及肠道屏障功能的影响--《浙江中西医结合杂志》2018年05期
大黄联合谷氨酰胺对急性肝衰竭模型大鼠肝功能及肠道屏障功能的影响
【摘要】：目的观察大黄联合谷氨酰胺(Gln)对急性肝衰竭(AHF)模型大鼠肝功能及肠道屏障功能的保护作用。方法 SD雄性大鼠60只,随机分成对照组、模型组和防治组(大黄联合谷氨酰胺),各20只。于造模前2天防治组大鼠给予1g/m L大黄煎液0.375m L/100g鼠重和3%Gln溶液0.375m L/100g鼠重灌胃,模型组与对照组大鼠给予0.9%生理盐水0.75m L/100g鼠重灌胃。第3天继续给药灌胃同时,参照文献方法,使用10%D-氨基半乳糖(D-Gal N)溶液按1500mg/kg鼠重给予模型组和防治组大鼠腹腔一次性注射,即完成造模。各组大鼠分别于造模后24、48、72、96h眼眶取血,测定血清总胆红素(TBil)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平,大鼠处死后,腹主动脉取血检测血清二胺氧化酶(DAO)水平,取大鼠肠组织并检测其DAO水平,取部分肝右叶对大鼠肝脏炎症的病理变化进行评分。结果模型组大鼠24h TBil(8.14±3.16)μmol/L、ALT(625.21±242.49)U/L、AST(9.69)U/L、48h TBil(51.78±20.57)μmol/L、ALT(65.70)U/L、AST(35.05)U/L和72h TBil(32.50±19.01)μmol/L、ALT(345.59±222.82)U/L、AST(883.41±312.02)U/L与对照组24h时TBil(0.01±0.02)μmol/L、ALT(5.41±2.81)U/L、AST(11.38±3.32)U/L、48h时TBil(0.06±0.04)μmol/L、ALT(5.28±2.42)U/L、AST(12.05±4.26)U/L和72h时TBil(-0.69±1.63)μmol/L、ALT(5.03±2.75)U/L、AST(11.79±2.38)U/L比较,差异有统计学意义(P0.01,P0.05);与模型组比较,防治组24h TBil(0.58±2.91)μmol/L、ALT(119.25±197.65)U/L、AST(248.30±343.85)U/L、48h TBil(8.18±14.27)μmol/L、ALT(346.58±464.84)U/L、AST(792.81±954.35)U/L和72h TBil(3.94±5.72)μmol/L、ALT(91.97±133.00)U/L、AST(178.59±288.41)U/L水平有明显降低,差异均有统计学意义(P0.05,P0.01)。对照组及防治组大鼠肝脏炎症的评分分别为0、(3.00±1.04)分,与模型组(7.75±0.46)分相比,差异均有统计学意义(P0.01)。对照组及防治组大鼠血清DAO水平皆低于模型组[(7.12±2.05)U/L、(8.96±1.99)U/L比(25.01±4.10)U/L],差异均有统计学意义(P0.01);对照组及防治组大鼠肠组织DAO水平明显高于模型组[(21.13±7.82)U/L、(18.30±3.35)U/L比(7.98±1.94)U/L],差异均有统计学意义(P0.01)。结论大黄联合Gln对AHF模型大鼠肝功能损伤和肠道功能紊乱有防治作用。
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